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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Cyclin-dependent Kinase (CDK)-GFB-12811
GFB-12811

Chemical Structure : GFB-12811

CAS No.: 2775311-17-4

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GFB-12811 (GFB12811)

货号: PC-72894Not For Human Use, Lab Use Only.

GFB-12811 (GFB12811) is a potent, highly selective CDK5 inhibitor with IC50 of 2.3 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GFB-12811 (GFB12811) is a potent, highly selective CDK5 inhibitor with IC50 of 2.3 nM.
GFB-12811 is highly selective (>100-fold) over other CDKs (CDK1/2/6/7/9).
GFB-12811 demonstrated CDK5 target engagement while avoiding anti-proliferative effects associated with inhibiting other CDKs in cellular assays.
GFB-12811 exhibite promising in vivo PK profiles, enabling the use as tool compounds for interrogating the role of CDK5 in autosomal dominant polycystic kidney disease (ADPKD) and other diseases.

物理化学性质&存储条件

分子量 449.454
分子式 C22H23F4N5O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-1-(7-((5-fluoro-2-(trifluoromethyl)pyridin-4-yl)amino)-1,6-naphthyridin-2-yl)-1-(1-methylpiperidin-4-yl)ethan-1-ol

参考文献

1. Daniels MH, et al. J Med Chem. 2022 Feb 24;65(4):3575-3596.

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