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首页-小分子抑制剂&激动剂-TGF-beta/Smad-PKC-GF109203X
GF109203X

Chemical Structure : GF109203X

CAS No.: 133052-90-1

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GF109203X (Bisindolylmaleimide I, Go 6805)

货号: PC-23426Not For Human Use, Lab Use Only.

GF109203X (Bisindolylmaleimide I) is a potent, cell-permeable and reversible PKC inhibitor with IC50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ respectively.

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10 mg ￥1080 In stock
25 mg ￥1980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GF109203X (Bisindolylmaleimide I, GF 109203X) is a potent, cell-permeable and reversible PKC inhibitor with IC50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ respectively.
GF109203X abrogates anti-CD3 antibody-induced upregulation of CD4+ T cell adhesion to B cells.
GF 109203X efficiently prevented PKC-mediated phosphorylations of an Mr = 47,000 protein in platelets and of an Mr = 80,000 protein in Swiss 3T3 cells.
GF 109203X inhibited collagen- and alpha-thrombin-induced platelet aggregation as well as collagen-triggered ATP secretion.

物理化学性质&存储条件

分子量 412.49
分子式 C25H24N4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(1-(3-(Dimethylamino)propyl)-1H-indol-3-yl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

参考文献

1. Hauss P, et al. Cell Immunol. 1993 Sep;150(2):439-46.

2. Toullec D, et al. J Biol Chem. 1991 Aug 25;266(24):15771-81.

3. Faucher C, et al. J Biol Chem. 1993 Jul 15;268(20):15168-73.

4. Paya CV, et al. Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7826-30.

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