GE1111 | MRGPRX2 inhibitor | Probechem Biochemicals

Chemical Structure : GE1111

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GE1111 (GE-1111)

货号: PC-49486Not For Human Use, Lab Use Only.

GE1111 is a novel potent small molecule Mas-related G protein-coupled receptor X2 (MRGPRX2) antagonist, significantly inhibits mast cells degranulation and MRGPRX2 activation with IC50 of 5 uM.

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生物&药学活性

GE1111 is a novel potent small molecule Mas-related G protein-coupled receptor X2 (MRGPRX2) antagonist, significantly inhibits mast cells degranulation and MRGPRX2 activation with IC50 of 5 uM.
GE1111 inhibited not only the early phase of mast cell activation but also the late phase, associated with chemokine and prostaglandin release, inhibited downstream PLC-γ, ERK1/2 and Akt signalling pathway.
GE1111 attenuated C48/80-induced mouse peritoneal mast cells degranulation, paw oedema and tissue extravasation in allergic mice models.

物理化学性质&存储条件

分子量	466.49
分子式	C28H22N2O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl 3-(2-formyl-9-hydroxy-1-methyl-1H-phenalen-5-yl)-7-ureido-2-naphthoate

参考文献

1. Kumar M, et al. J Allergy Clin Immunol. 2022 Dec 26:S0091-6749(22)02551-9.

GE1111 (GE-1111)

生物&药学活性

物理化学性质&存储条件

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GE1111 (GE-1111)

生物&药学活性

物理化学性质&存储条件

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