GDU-952 | AhR agonist | Probechem Biochemicals

Chemical Structure : GDU-952

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GDU-952 (GDU952)

货号: PC-21481Not For Human Use, Lab Use Only.

GDU-952 is a novel small molecule aryl hydrocarbon receptor (AhR) agonist, activates and induces nuclear translocation of AhR.

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生物&药学活性

GDU-952 is a novel small molecule aryl hydrocarbon receptor (AhR) agonist, activates and induces nuclear translocation of AhR.
GDU-952 (1 uM) treatment obviously increased CYP1A1 generation, induces nuclear translocation of AhR in RAW264.7 macrophages.
GDU-952 decreases IgE serum levels, to inhibit pro-inflammatory cytokines such as IL-6 and TNF-α and to induce immunoregulatory effects through restoring Th1/Th2 immune balance and promoting CD4+FOXP3+regulatory T (Treg) populations in AD skin lesions.

物理化学性质&存储条件

分子量	284.37
分子式	C17H16O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-2-(cyclopent-1-en-1-yl)-5-(2-(thiophen-3-yl)vinyl)benzene-1,3-diol

参考文献

1. Liang YH, et al. Biochem Pharmacol. 2023 Nov;217:115835.

GDU-952 (GDU952)

生物&药学活性

物理化学性质&存储条件

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GDU-952 (GDU952)

生物&药学活性

物理化学性质&存储条件

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