GDC-0879 |CAS:905281-76-7 Probechem Biochemicals

Chemical Structure : GDC-0879

CAS No.: 905281-76-7

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GDC-0879 (GDC0879;GDC 0879)

货号: PC-45877Not For Human Use, Lab Use Only.

A potent and selective B-Raf kinase inhibitor with IC50 of 0.13 nM against purified B-Raf V600E and a cellular pERK IC50 of 63 nM in the MALME-3M cell line.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

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生物&药学活性

GDC-0879 is a potent and selective B-Raf kinase inhibitor with IC50 of 0.13 nM against purified B-Raf V600E and a cellular pERK IC50 of 63 nM in the MALME-3M cell line.
GDC-0879 shows expected activity only against C-Raf against a panel of 140 kinases at 1 uM.
GDC-0879 shows comparable potency in A375 melanoma and Colo205 colorectal carcinoma cell lines with IC50 of 59 nM and 29 nM for pMEK1 inhibition respectively.
GDC-0879 shows tumor growth inhibition in A375 xenografts; orally active.

物理化学性质&存储条件

分子量	334.3718
分子式	C19H18N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Inden-1-one, 2,3-dihydro-5-[1-(2-hydroxyethyl)-3-(4-pyridinyl)-1H-pyrazol-4-yl]-, oxime

参考文献

1. Wong H, et al. J Pharmacol Exp Ther. 2009 Apr;329(1):360-7.

2. Hoeflich KP, et al. Cancer Res. 2009 Apr 1;69(7):3042-51.

3. Hansen JD, et al. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4692-5.

GDC-0879 (GDC0879;GDC 0879)

生物&药学活性

物理化学性质&存储条件

参考文献

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询单

GDC-0879 (GDC0879;GDC 0879)

生物&药学活性

物理化学性质&存储条件

参考文献

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