GDC-046 |CAS:1258292-64-6 Probechem Biochemicals

Chemical Structure : GDC-046

CAS No.: 1258292-64-6

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GDC-046 (GDC046)

货号: PC-38049Not For Human Use, Lab Use Only.

GDC-046 is a potent, selective, and orally bioavailable inhibitor of TYK2 with with Kis of 4.8, 0.7, 0.7, and 0.4 nM for TYK2, JAK1, JAK2, and JAK3, respectively.

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10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg	￥3980	In stock
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生物&药学活性

GDC-046 is a potent, selective, and orally bioavailable inhibitor of TYK2 with with Kis of 4.8, 0.7, 0.7, and 0.4 nM for TYK2, JAK1, JAK2, and JAK3, respectively.
GDC-046 demonstrates reasonable potency in blocking the IL-12 pathway (IL-12 pSTAT4 EC50=380 nM) in cell based assays.
GDC-046 also displays less activity in the EPO (JAK2) pathway (EPO pSTAT5 EC50=1700 nM), and IL-6 (JAK1) pathway (IL-6 pSTAT3 EC50=2000 nM).
GDC-046 shows statistically significant knockdown of cytokine interferon-γ (IFNγ), in a mouse IL-12 PK/PD model.

物理化学性质&存储条件

分子量	350.199
分子式	C16H13Cl2N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide

GDC-046 (GDC046)

生物&药学活性

物理化学性质&存储条件

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GDC-046 (GDC046)

生物&药学活性

物理化学性质&存储条件

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