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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-MEKK (MAP3K)-GDC-0134
GDC-0134

Chemical Structure : GDC-0134

CAS No.: 1637394-01-4

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GDC-0134 (GDC0134)

货号: PC-72890Not For Human Use, Lab Use Only.

GDC-0134 (GDC0134) is a potent, selective, orally available, brain-penetrant inhibitor of dual leucine zipper kinase (DLK, MAP3K12).

规格 价格 库存 数量
2 mg ￥2180 In stock
5 mg ￥3880 In stock
10 mg ￥5880 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: 97.1% (HPLC) Select Batch:

生物&药学活性

GDC-0134 (GDC0134) is a potent, selective, orally available, brain-penetrant inhibitor of dual leucine zipper kinase (DLK, MAP3K12).
GDC‐0134 blocks DLK activity in cellular assays and in animal models of neuronal injury.
Dual leucine zipper kinase (DLK), which regulates the c‐Jun N‐terminal kinase pathway involved in axon degeneration and apoptosis following neuronal injury, is a potential therapeutic target in amyotrophic lateral sclerosis (ALS).

物理化学性质&存储条件

分子量 440.403
分子式 C19H20F4N6O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-(6-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-2-(3,3-difluoropyrrolidin-1-yl)pyrimidin-4-yl)-3-(difluoromethoxy)pyridin-2-amine

参考文献

1. Jonathan S Katz, et al. Ann Clin Transl Neurol. 2022 Jan;9(1):50-66.

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