Paxalisib (GDC-0084, RG7666) | PI3K/mTOR inhibitor | Probechem Biochemicals

Chemical Structure : GDC-0084

CAS No.: 1382979-44-3

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GDC-0084 (Paxalisib, RG7666, GDC0084)

货号: PC-45766Not For Human Use, Lab Use Only.

Paxalisib (GDC-0084, RG7666) is a potent, selective, brain penetrant dual inhibitor of class I PI3Ks and mTOR with Ki of 2/46/3/10/70 nM for PI3Kα/β/δ/γ/mTOR, respectively.

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5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
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生物&药学活性

Paxalisib (GDC-0084, RG7666) is a potent, selective, brain penetrant dual inhibitor of class I PI3Ks and mTOR with Ki of 2/46/3/10/70 nM for PI3Kα/β/δ/γ/mTOR, respectively.
Paxalisib (GDC-0084, RG7666) is highly selective against a panel of 229 kinases (IC50>1 uM).
Paxalisib (GDC-0084, RG7666) shows antiproliferative (EC50 =0.3-1.1 uM) in 5 GBM cell lines.
Paxalisib (GDC-0084, RG7666) significantly and dose-dependently inhibits tumor growth in a subcutaneous U87 tumor xenograft model of glioblastoma in mice.

物理化学性质&存储条件

分子量	382.4197
分子式	C18H22N8O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 6 mg/mL (Need ultrasonic)
Chemical Name/SMILES	2-Pyrimidinamine, 5-[8,9-dihydro-6,6-dimethyl-4-(4-morpholinyl)-6H-[1,4]oxazino[4,3-e]purin-2-yl]-

参考文献

1. Heffron TP, et al. ACS Med Chem Lett. 2016 Feb 16;7(4):351-6.

2. Salphati L, et al. Drug Metab Dispos. 2016 Dec;44(12):1881-1889.

GDC-0084 (Paxalisib, RG7666, GDC0084)

生物&药学活性

物理化学性质&存储条件

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GDC-0084 (Paxalisib, RG7666, GDC0084)

生物&药学活性

物理化学性质&存储条件

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