GD433 | NTMT1 inhibitor | Probechem Biochemicals

Chemical Structure : GD433

加入收藏

GD433 (GD-433)

货号: PC-26565Not For Human Use, Lab Use Only.

GD433 is a potent, selective and substrate competitive inhibitor of N-terminal methyltransferase 1 (NTMT1) with IC50 of 27 nM.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

GD433 is a potent, selective and substrate competitive inhibitor of N-terminal methyltransferase 1 (NTMT1) with IC50 of 27 nM.
GD433 interacts with NTMT1 with a dissociation constant (Kd) of 36.9 nM.
GD433 is selective for NTMT1/2 over 40 other methyltransferases (G9a, PRMT1, PRMT7, NNMT, and SETD7).
GD433 potently inhibits NTMT1 and its close homolog NTMT2.
GD433 significantly reduces me3-RCC1 and me3-SET with an approximate IC50 value of <30 nM in HEK293 cells.
GD433 promotes myogenic differentiation and enhances muscle regeneration in mdx mice.

物理化学性质&存储条件

分子量	405.49
分子式	C20H24FN3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-quinuclidin-3-yl (2-(2-(4-fluoro-3-hydroxyphenyl)thiazol-4-yl)propan-2-yl)carbamate

参考文献

1. Deng Y, et al. J Med Chem. 2023 Jan 26;66(2):1601-1615.

2. Zhang H, et al. Stem Cell Res Ther. 2026 Apr 15;17(1):139.

GD433 (GD-433)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

GD433 (GD-433)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.