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首页-小分子抑制剂&激动剂-Others-Other Targets-GCS-12
GCS-12

Chemical Structure : GCS-12

CAS No.:

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GCS-12 (GCS12)

货号: PC-22755Not For Human Use, Lab Use Only.

GCS-12 is a highly potent αGalCer sulfonamide analogue as natural killer T (NKT) cell agonist, enhances interaction of the glycolipid/CD1d complex, exhibits selectivity for the induction of IFN-γ over IL-4, shows potent antitumor activities.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

GCS-12 is a highly potent αGalCer sulfonamide analogue as natural killer T (NKT) cell agonist, enhances interaction of the glycolipid/CD1d complex, exhibits selectivity for the induction of IFN-γ over IL-4, shows potent antitumor activities.

物理化学性质&存储条件

分子量 909.36
分子式 C48H96N2O11S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-((2S,3S,4R)-3,4-Dihydroxy-1-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)octadecan-2-yl)-12-(dodecylsulfonamido)dodecanamide

参考文献

1. Yu Wen, et al. J Med Chem. 2024 Jul 20. doi: 10.1021/acs.jmedchem.4c00782.

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