GC376 |CAS:1416992-39-6 Probechem Biochemicals

Chemical Structure : GC376

CAS No.: 1416992-39-6

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GC376 (GC-376)

货号: PC-35231Not For Human Use, Lab Use Only.

GC376 (GC-376) is a broad-spectrum antiviral agent that inhibits 3C or 3C-like proteases (3Cpro or 3CLpro) of picornaviruses, noroviruses, and coronaviruses with IC50 of 0.96 (MD145), 0.82 (TGEV) and 0.2 uM (HRV) in FRET protease assays.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3280	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

GC376 (GC-376) is a broad-spectrum antiviral agent that inhibits 3C or 3C-like proteases (3Cpro or 3CLpro) of picornaviruses, noroviruses, and coronaviruses with IC50 of 0.96 (MD145), 0.82 (TGEV) and 0.2 uM (HRV) in FRET protease assays.
GC376 demonstrates significant effectivities against caliciviruses (NV and MNV-1), coronaviruses (TGEV, FIPV, MHV, 229E, and BCV), and picornaviruses (HRVs 18, 51, and 68 (EC50=0.3-1.5 uM), EV71 (EC50=10.3 uM), and PTV).
GC376 showed promise in treating cats with certain presentations of feline infectious peritonitis.

物理化学性质&存储条件

分子量	507.534
分子式	C21H30N3NaO8S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	sodium (2S)-2-((S)-2-(((benzyloxy)carbonyl)amino)-4-methylpentanamido)-1-hydroxy-3-(2-oxopyrrolidin-3-yl)propane-1-sulfonate

参考文献

1. Kim Y, et al. J Virol. 2012 Nov;86(21):11754-62.

2. Takahashi D, et al. Virus Res. 2013 Dec 26;178(2):437-44.

3. Pedersen NC, et al. J Feline Med Surg. 2018 Apr;20(4):378-392.

GC376 (GC-376)

生物&药学活性

物理化学性质&存储条件

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GC376 (GC-376)

生物&药学活性

物理化学性质&存储条件

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