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首页-新冠病毒相关-SARS-CoV-2 Inhibitors-GC-78-HCl
GC-78-HCl

Chemical Structure : GC-78-HCl

CAS No.:

GC-78-HCl

货号: PC-21451Not For Human Use, Lab Use Only.

GC-78-HCl is a potent nonpeptide SARS-CoV-2 main protease (Mpro) inhibitor with IC50 of 0.19 uM, exhibits excellent antiviral activity (EC50=0.4 uM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

GC-78-HCl is a potent nonpeptide SARS-CoV-2 main protease (Mpro) inhibitor with IC50 of 0.19 uM, exhibits excellent antiviral activity (EC50=0.4 uM).
GC-78-HCl displays potent antiviral activities against various SARS-CoV-2 variants as well as HCoV-OC43 and HCoV-229E, indicating its potential broad-spectrum anticoronaviral activity.

物理化学性质&存储条件

分子量 551.85
分子式 C25H25Cl3N4O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-1-(3,4-dichlorophenyl)-4-(4-methoxynicotinoyl)-N-(4-methoxyphenyl)piperazine-2-carboxamide hydrochloride

参考文献

1. Shenghua Gao, et al. Journal of Medicinal Chemistry 2023

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