GC-14 | SARS-CoV-2 Mpro inhibitor | Probechem Biochemicals

Chemical Structure : GC-14

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GC-14 (SARS-CoV-2 Mpro inhibitor)

货号: PC-49342Not For Human Use, Lab Use Only.

GC-14 is a potent, selective and non-covalent non-peptide SARS-CoV-2 main protease (Mpro) inhibitor with IC50 of 0.4 uM, displays excellent selectivity over cathepsins B, F, K, L, and caspase 3 (IC50>50 uM).

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

GC-14 is a potent, selective and non-covalent non-peptide SARS-CoV-2 main protease (Mpro) inhibitor with IC50 of 0.4 uM, displays excellent selectivity over cathepsins B, F, K, L, and caspase 3 (IC50>50 uM).
GC-14 displays excellent antiviral activity (EC50 = 1.1 μM), being more potent than Remdesivir.
GC-14 exhibits low cytotoxicity (CC50>100 μM).
GC-14 occupys multiple subpockets by critical non-covalent interactions.

物理化学性质&存储条件

分子量	475.388
分子式	C22H20Cl2N4O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1-(3,4-dichlorophenyl)-4-nicotinoyl-N-(thiophen-2-ylmethyl)piperazine-2-carboxamide

参考文献

1. Gao S, et al. J Med Chem. 2022 Sep 15. doi: 10.1021/acs.jmedchem.2c01146.