GBT1118 | Hemoglobin modifier | Probechem Biochemicals

Chemical Structure : GBT1118

CAS No.: 1628799-51-8

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GBT1118 (GBT-1118)

货号: PC-47075Not For Human Use, Lab Use Only.

GBT1118 is a potent, orally bioavailable allosteric modifier of hemoglobin O2 affinity, binds covalently and reversibly via an imine intermediate to the NH2-terminal valine of the Hb α-chain.

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10 mg	￥2180	In stock
25 mg	￥3880	In stock
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生物&药学活性

GBT1118 is a potent, orally bioavailable allosteric modifier of hemoglobin O2 affinity, binds covalently and reversibly via an imine intermediate to the NH2-terminal valine of the Hb α-chain.
GBT1118 increased Hb O2 affinity and decreased the Po2 during hypoxia in awake-instrumented mice.
GBT1118 significantly attenuated bleomycin-induced lung fibrosis, collagen accumulation, body weight loss, and leukocyte infiltration in a bleomycin-induced mouse model of hypoxemia and fibrosis.
GBT1118 significantly improved tolerance to hypoxia in sickle cell mice.

物理化学性质&存储条件

分子量	340.379
分子式	C19H20N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzaldehyde, 2-hydroxy-6-[[(2S)-1-(3-pyridinylcarbonyl)-2-piperidinyl]methoxy]-

参考文献

1. Geng X, et al. Physiol Rep. 2016 Sep;4(17):e12965.

2. Dufu K, et al. Am J Physiol Heart Circ Physiol. 2017 Aug 1;313(2):H381-H391.

3. Dufu K, et al. Am J Physiol Heart Circ Physiol. 2021 Aug 1;321(2):H400-H411.

GBT1118 (GBT-1118)

生物&药学活性

物理化学性质&存储条件

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GBT1118 (GBT-1118)

生物&药学活性

物理化学性质&存储条件

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