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首页-小分子抑制剂&激动剂-Others-Other Targets-GBT-440
GBT-440

Chemical Structure : GBT-440

CAS No.: 1446321-46-5

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GBT-440 (GBT 440, GBT440, Voxelotor)

货号: PC-45522Not For Human Use, Lab Use Only.

GBT-440 (Voxelotor) is a new potent allosteric effector of sickle cell hemoglobin, inhibits haemoglobin S (HbS) polymerization.

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10 mg ￥780 In stock
25 mg ￥1380 In stock
50 mg ￥2280 In stock
100 mg ￥3480 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GBT-440 (Voxelotor) is a new potent allosteric effector of sickle cell hemoglobin, inhibits haemoglobin S (HbS) polymerization.
GBT-440 (Voxelotor) increases the affinity of hemoglobin for oxygen and consequently inhibits its polymerization when subjected to hypoxic conditions.
GBT-440 (Voxelotor) is orally bioavailable and partitions highly and favorably into the red blood cell with a RBC/plasma ratio of ∼150.

物理化学性质&存储条件

分子量 337.3725
分子式 C19H19N3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Benzaldehyde, 2-hydroxy-6-[[2-[1-(1-methylethyl)-1H-pyrazol-5-yl]-3-pyridinyl]methoxy]-

参考文献

1. Metcalf B, et al. ACS Med Chem Lett. 2017 Jan 23;8(3):321-326.

2. Oksenberg D, et al. Br J Haematol. 2016 Oct;175(1):141-53.

3. Dufu K, et al. Hematol Rep. 2016 Sep 28;8(3):6637.

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