GATA4-IN-3 |CAS:544681-96-1 Probechem Biochemicals

Chemical Structure : GATA4-IN-3

CAS No.: 544681-96-1

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GATA4-IN-3 (GATA4 inhibitor 3)

货号: PC-61050Not For Human Use, Lab Use Only.

GATA4-IN-3 is a novel small molecule that inhibits GATA4/NKX2-5 transcriptional synergy with IC50 of 3 uM, with no activity on the protein kinases involved in the regulation of GATA4 phosphorylation.

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5 mg	￥1880	In stock
10 mg	￥3280	In stock
25 mg	￥5280	In stock
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100 mg		Get quote

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生物&药学活性

GATA4-IN-3 is a novel small molecule that inhibits GATA4/NKX2-5 transcriptional synergy with IC50 of 3 uM, with no activity on the protein kinases involved in the regulation of GATA4 phosphorylation.
GATA4-IN-3 also inhibits the ET-1-stimulated BNP gene expression.
GATA4-IN-3 inhibits hypertrophic growth in a cardiomyocyte hypertrophy model, without effect on apoptotic cell death.

物理化学性质&存储条件

分子量	349.434
分子式	C21H23N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[4-(diethylamino)phenyl]-5-methyl-3-phenylisoxazole-4-carboxamide

参考文献

1. Välimäki MJ, et al. J Med Chem. 2017 Sep 28;60(18):7781-7798.

GATA4-IN-3 (GATA4 inhibitor 3)

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物理化学性质&存储条件

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GATA4-IN-3 (GATA4 inhibitor 3)

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物理化学性质&存储条件

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