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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-nAChR-GAT2711
GAT2711

Chemical Structure : GAT2711

CAS No.:

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GAT2711 (GAT-2711)

货号: PC-22294Not For Human Use, Lab Use Only.

GAT2711 is a potent, selective full agonist of α9 nAChR with EC50 of 230 nM, 340-fold selective over α7 nAChR.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

GAT2711 is a potent, selective full agonist of α9 nAChR with EC50 of 230 nM, 340-fold selective over α7 nAChR.
GAT2711 significantly and dose-dependently inhibited (IC50= 0.5 μM) the BzATP-induced release of IL-1β in human monocytic THP-1 cells.
GAT2711  (10 mg/kg body weight) fully attenuated inflammatory pain in an α7 nAChR-independent manner in CFA-induced chronic inflammatory pain model.

物理化学性质&存储条件

分子量 466.37
分子式 C20H27IN4O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-Ethyl-1-methyl-4-(4-(6-methylpicolinamido)phenyl)piperazin-1-ium Iodide

参考文献

1. Andleeb H, et al. J Med Chem. 2024 May 15. doi: 10.1021/acs.jmedchem.3c02429.

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