GAP-134 hydrochloride | Gap-junction modifier | Probechem Biochemicals

Chemical Structure : GAP-134 hydrochloride

CAS No.: 943133-81-1

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GAP-134 hydrochloride (Danegaptide hydrochlorid, ZP1609 hydrochloride, GAP134 hydrochloride)

货号: PC-42736Not For Human Use, Lab Use Only.

Danegaptide (GAP-134, ZP1609) is a potent, orally active gap-junction modifier, prevents significantly conduction velocity slowing at 10 nM compared with vehicle.

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5 mg	￥1380	In stock
10 mg	￥2180	In stock
25 mg	￥3780	In stock
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100 mg		Get quote

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生物&药学活性

Danegaptide (GAP-134, ZP1609) is a potent, orally active gap-junction modifier, prevents significantly conduction velocity slowing at 10 nM compared with vehicle.
Danegaptide (GAP-134, ZP1609) has highly desirable in vitro and in vivo safety profile including (1) lack of direct effects on membrane ion currents, hERG inhibition, and CYP450 liabilities, (2) negative AMES result, (3) a benign NovaScreen profile, and (4) no effects on systemic hemodynamics.

物理化学性质&存储条件

分子量	327.7634
分子式	C14H18ClN3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	L-Proline, glycyl-4-(benzoylamino)-, hydrochloride (1:1), (4R)-

参考文献

1. Butera JA, et al. J Med Chem. 2009 Feb 26;52(4):908-11.

2. Rossman EI, et al. J Pharmacol Exp Ther. 2009 Jun;329(3):1127-33.

3. Hennan JK, et al. J Cardiovasc Pharmacol Ther. 2009 Sep;14(3):207-14.

GAP-134 hydrochloride (Danegaptide hydrochlorid, ZP1609 hydrochloride, GAP134 hydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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GAP-134 hydrochloride (Danegaptide hydrochlorid, ZP1609 hydrochloride, GAP134 hydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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