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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-Gli-GANT61
GANT61

Chemical Structure : GANT61

CAS No.: 500579-04-4

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GANT61 (GANT 61, GANT-61, NSC 136476)

货号: PC-27229Not For Human Use, Lab Use Only.

GANT61 (GANT-61) is a specific small molecule inhibitor of GLI1 and GLI2, inhibits Hedgehog (Hh) signaling pathway with IC50 of 5 uM in Gli reporter assays using murine NIH 3T3 cell line.

规格 价格 库存 数量
10 mg ￥780 In stock
25 mg ￥1280 In stock
50 mg ￥1980 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GANT61 (GANT-61) is a specific small molecule inhibitor of GLI1 and GLI2, inhibits Hedgehog (Hh) signaling pathway with IC50 of 5 uM in Gli reporter assays using murine NIH 3T3 cell line.
GANT61 acts in the nucleus to block Gli function, inhibits both Gli1- and Gli2- mediated transcription, and demonstrates a high degree of selectivity for HH/Gli signaling.
GANT61 inhibits Hh signaling downstream of Smo and Sufu.
GANT61 inhibits GLI-dependent human tumor cell growth.
GANT61 (50 mg/kg) blocks GLI function and subsequent cell growth, induces growth regression in human prostate cancer xenograft.

物理化学性质&存储条件

分子量 429.61
分子式 C27H35N5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2,2'-((2-(Pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl)bis(methylene))bis(N,N-dimethylaniline)

参考文献

1. Lauth M, et al. Mol Pharmacol. 2010 Sep;78(3):486-96.

2. Desch P, et al. Oncogene. 2010 Sep 2;29(35):4885-95.

3. Mazumdar T, et al. Cancer Res. 2011 Feb 1;71(3):1092-102.

4. Lauth M, et al. Proc Natl Acad Sci U S A. 2007;104:8455–60.

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