GAK inhibitor 12r |CAS: 2241325-66-4 Probechem Biochemicals

Chemical Structure : GAK inhibitor 12r

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GAK inhibitor 12r

货号: PC-35411Not For Human Use, Lab Use Only.

GAK inhibitor 12r is a higghly potent, selective inhibitor of cyclin G-associated kinase (GAK) with Kd of 89 nM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

GAK inhibitor 12r is a higghly potent, selective inhibitor of cyclin G-associated kinase (GAK) with Kd of 89 nM.
GAK inhibitor 12r targets only 8 other kinases with greater than 90% inhibition in a diverse panel of 468 kinases.
GAK inhibitor 12r demonstrates broad-spectrum antiviral activity with EC50 of 0.82 uM against DENV-2, also shows activity against dengue virus, including in human primary dendritic cells, and efficacy against the unrelated Ebola and chikungunya viruses.

物理化学性质&存储条件

分子量	370.471
分子式	C19H22N4O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(3-(cis-2,6-Dimethylmorpholino)isothiazolo[4,3-b]pyridin-6-yl)-2-methoxyaniline

参考文献

1. Pu SY, et al. J Med Chem. 2018 Jul 16. doi: 10.1021/acs.jmedchem.8b00613.