GAC0001E5 | LXR inverse agonist | Probechem Biochemicals

Chemical Structure : GAC0001E5

CAS No.: 927969-67-3

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GAC0001E5 (LXR ligand 1E5)

货号: PC-49867Not For Human Use, Lab Use Only.

GAC0001E5 (LXR ligand 1E5) is a small molecule liver X receptor (LXR) inverse agonist and a potent inhibitor of pancreatic and breast cancer cells (MDA-MB-231, IC50=7.74 uM).

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5 mg	￥2180	In stock
10 mg	￥3580	In stock
25 mg	￥5580	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

GAC0001E5 (LXR ligand 1E5) is a small molecule liver X receptor (LXR) inverse agonist and a potent inhibitor of pancreatic and breast cancer cells (MDA-MB-231, IC50=7.74 uM).
GAC0001E5 significantly decreased LXRβ transcription and translation in MCF7-TamR and MDA-MB-231 cells.
GAC0001E5 induces oxidative stress in breast cancer cells, disrupting glutaminolysis, downregulates the intracellular glutamate levels.
Combination treatment of 1E5 with GLS inhibitor BPTES synergistically decreases glutaminolysis and growth of PDAC cells.

物理化学性质&存储条件

分子量	331.30
分子式	C17H12F3N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-phenyl-2-((3-(trifluoromethyl)phenyl)amino)pyrimidin-4(3H)-one

参考文献

1. Srivastava S, et al. Int J Mol Sci. 2020 Dec 17;21(24):9622.

2. Premaratne A, et al. Biomolecules. 2023 Feb 10;13(2):345.

3. araboga H, et al. ACS Chem Biol. 2020;15:2916–2928.

GAC0001E5 (LXR ligand 1E5)

生物&药学活性

物理化学性质&存储条件

参考文献

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GAC0001E5 (LXR ligand 1E5)

生物&药学活性

物理化学性质&存储条件

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