Chemical Structure : GABAA receptor agonist CTMB
CAS No.:
3058976-94-3
GABAA receptor agonist CTMB
货号: PC-24988Not For Human Use, Lab Use Only.
CTMB is an allosteric agonist of GABAA receptors, positively modulates GABAA receptors and inhibits voltage-regulated sodium channels (NaVs) to suppress neuronal membrane depolarization.
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纯度 & COA & 质检文件 纯度:
>98% (HPLC)
生物&药学活性
CTMB is an allosteric agonist of GABAA receptors, positively modulates GABAA receptors and inhibits voltage-regulated sodium channels (NaVs) to suppress neuronal membrane depolarization.
CTMB inhibits the firing activity of interneurons via GABAA receptors and NaVs.
CTMB increases the cell viability and reduces the apoptosis of mechanically scratched HT22 cells through modulation of GABAA receptors.
CTMB (30mg/kg) reduces the area of brain damage and attenuates neurobehavioral deficits at 7 days after traumatic brain injury (TBI).
CTMB (30mg/kg) improves the rats' sensory and motor functions of limbs and attenuates neuronal damage in the subacute phase of traumatic brain injury (TBI).
CTMB mitigates mitochondrial-involved neuronal apoptosis by attenuating the cascading neuro-excitotoxicity of GABAA receptors during the subacute phase of traumatic brain injury (TBI).
CTMB prolonged survival, reduced epilepsy and improved long-term motor ability during the recovery phase of traumatic brain injury (TBI) rats.
物理化学性质&存储条件
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分子量
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234.30
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分子式
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C14H18O3
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外观性状
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Solid
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CAS No.
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储存条件
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- 固体粉末
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-20°C 12 个月; 4°C 6 个月
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- 配置液
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-80°C 6 个月; -20°C 6 个月
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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1-(cyclobutylidenemethyl)-2,4,5-trimethoxybenzene
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参考文献
1. Ruijie Yan, et al. Br J Pharmacol. 2025 Jun 24. doi: 10.1111/bph.70117.
