G721-0282

Chemical Structure : G721-0282

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货号: PC-23541Not For Human Use, Lab Use Only.

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生物&药学活性

G721-0282 is a specific small molecule inhibitor of chitinase-3 like-protein-1 (CHI3L1, YKL-40), inhibits cell growth and induces apoptosis in human osteosarcoma through down-regulation of the STAT3 pathway.
G721-0282 inhibits cell growth in osteosarcoma cells, induces apoptosis and cell cycle arrests in MG63 and U2OS cells.
G721-0282 regulates apoptotic regulatory proteins and MAPK proteins, inhibits the STAT3 pathways.
G721-0282 inhibits cell migration, invasion and in vitro colony formation.
G721-0282 inhibits tumorigenesis in in vivo xenograft nude mice. G721-0282 inhibited the phosphorylation of Src kinase and the phosphorylation of STAT3.
G721-0282 reduced the expression of the STAT3 target proteins, Bcl-2 and Survivin.

物理化学性质&存储条件

分子量	376.48
分子式	C18H24N4O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-allyl-2-((6-butyl-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-5-yl)thio)acetamide

参考文献

1. Park KR, et al. Int J Biol Sci. 2020 Jan 1;16(2):330-341.

2. Rusak A, et al. Res Sq [Preprint]. 2024 Sep 24:rs.3.rs-4963939.

3. Rusak A, et al. Biomed Pharmacother. 2023 May;161:114520.

G721-0282

生物&药学活性

物理化学性质&存储条件

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G721-0282

生物&药学活性

物理化学性质&存储条件

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