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G6PD activator AG1

Chemical Structure : G6PD activator AG1

CAS No.: 421581-52-4

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G6PD activator AG1 (AG1)

货号: PC-35706Not For Human Use, Lab Use Only.

G6PD activator AG1 (AG1) is a specific, small molecule that increases the activity of the wild-type, Canton mutant (R459L, EC50=3 uM) and several other common glucose-6-phosphate dehydrogenase (G6PD) mutants.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

G6PD activator AG1 (AG1) is a specific, small molecule that increases the activity of the wild-type, Canton mutant (R459L, EC50=3 uM) and several other common glucose-6-phosphate dehydrogenase (G6PD) mutants.
AG1 displays no effect on the dimerization or activity of several other NAD- or NADP+-dependent dimeric or tetrameric enzymes, including 6PGD, GAPDH, ALDH2, and ALDH3A1.
AG1 attenuates ROS-induced pericardial edema in a G6PD-dependent manner in zebrafish, reduces hemolysis of human erythrocytes

物理化学性质&存储条件

分子量 438.652
分子式 C24H30N4S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2,2'-disulfanediylbis(N-(2-(1H-indol-3-yl)ethyl)ethan-1-amine)

参考文献

1. Hwang S, et al. Nat Commun. 2018 Oct 2;9(1):4045.

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