欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Others-Other Targets-G3BP inhibitor b
G3BP inhibitor b

Chemical Structure : G3BP inhibitor b

CAS No.: 3036029-78-1

加入收藏

G3BP inhibitor b (G3Ib)

货号: PC-21745Not For Human Use, Lab Use Only.

G3BP inhibitor b (G3Ib) is a specific, peptide mimetic inhibitor of RNA-binding proteins G3BP1/2 with SPR Kd value of 0.15 uM, blocks the association of G3BP with its binding partners and inhibits condensation of G3BP both in vitro and in live cells.

规格 价格 库存 数量
50 mg Get quote
100 mg Get quote
200 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    G3BP inhibitor b (G3Ib) is a specific, peptide mimetic inhibitor of RNA-binding proteins G3BP1/2 with SPR Kd value of 0.15 uM, blocks the association of G3BP with its binding partners and inhibits condensation of G3BP both in vitro and in live cells.
    G3BP inhibitor b (G3Ib) binds the NTF2L domain of G3BP1, disrupts in vitro condensation of RNA, G3BP1, and caprin 1.
    G3BP inhibitor b (G3Ib) (50 uM) inhibits stress granule formation in HeLa cells about 82%.
    G3BP inhibitor b (G3Ib) (50 uM) reduces eIF3η, PABPC1, and FXR1 puncta, indicating disassembly of stress granules beyond simple extraction of G3BP1, does not influence the rate of translation in cells.
    G3BP inhibitor b (G3Ib) prevents the formation of stress granules and dissolves preformed stress granules in human iPSC-derived neurons, dissolves stress granules formed in response to expression of a disease-causing VCP mutant.

    物理化学性质&存储条件

    分子量 606.81
    分子式 C35H50N4O5
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-((S)-3-hydroxy-3-methyl-1-oxo-1-(((2S,3S)-1-oxo-1-(((R)-1-oxo-1-((R)-2-phenylpyrrolidin-1-yl)propan-2-yl)amino)-3-phenylbutan-2-yl)amino)butan-2-yl)-4,4-dimethylpentanamide

    参考文献

    1. Freibaum BD, et al. J Cell Biol. 2024 Mar 4;223(3):e202308083.

    备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    联系我们 sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    询单

    • *产品名称:
    • *姓名:
    • *邮箱:
    • *公司名称:
    • *询单数量:
    • *国籍:
    • 询单信息: