G3BP1 inhibitor 129 | G3BP1/2 inhibitor | Probechem Biochemicals

Chemical Structure : G3BP1 inhibitor 129

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G3BP1 inhibitor 129 (G3BP1 inhibitor #129)

货号: PC-23716Not For Human Use, Lab Use Only.

G3BP1 inhibitor #129 is a small molecule ligand of G3BP1/2 (Ras-GTPase-activating protein SH3 domain-binding protein 1/2), binds with G3BP1 NTF2L domain with SPR KD of 3.7 uM, prevents stress granules (SGs) formation by disrupting G3BP1/caprin1 interaction.

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G3BP1 inhibitor #129 is a small molecule ligand of G3BP1/2 (Ras-GTPase-activating protein SH3 domain-binding protein 1/2), binds with G3BP1 NTF2L domain with SPR KD of 3.7 uM, prevents stress granules (SGs) formation by disrupting G3BP1/caprin1 interaction.

物理化学性质&存储条件

分子量	491.56
分子式	C26H25N3O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-3-((2-(1H-indazol-1-yl)-2-oxoethyl)sulfonyl)-2-benzyl-N-(4-methoxyphenyl)propanamide

参考文献

1. Dong T, et al. J Am Chem Soc. 2024 Dec 22.

G3BP1 inhibitor 129 (G3BP1 inhibitor #129)

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物理化学性质&存储条件

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G3BP1 inhibitor 129 (G3BP1 inhibitor #129)

生物&药学活性

物理化学性质&存储条件

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