G150 | cGAS inhibitor | Probechem Biochemicals

Chemical Structure : G150

CAS No.: 2369751-30-2

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G150 (cGAS inhibitor G150)

货号: PC-73361Not For Human Use, Lab Use Only.

G150 is a potent, specific human cyclic GMP-AMP synthase (cGAS) small-molecule inhibitor with IC50 of 10.2 nM, shows no inhibition against m-cGAS.

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10 mg	￥3880	In stock
25 mg	￥5580	In stock
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生物&药学活性

G150 is a potent, specific human cyclic GMP-AMP synthase (cGAS) small-molecule inhibitor with IC50 of 10.2 nM, shows no inhibition against m-cGAS.
G150 binds to apo h-cGASCD, localized within the ATP and GTP binding pocket.
G150 showed dose-dependent inhibitory activity in THP1 cells with IC50 of 1.96 uM, as determined by qRT-PCR for IFNB1 mRNA.
G150 shows no off-target effect against other nucleotidyl transferase enzymes.
G150 inhibits the SEAP NF-κB pathway reporter with IC50 of 0.9 uM.

物理化学性质&存储条件

分子量	391.25
分子式	C18H16Cl2N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO (3.9 mg/mL)
Chemical Name/SMILES	Ethanone, 1-[9-(6-amino-3-pyridinyl)-6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl]-2-hydroxy-

参考文献

1. Lodoe Lama, et al. Nat Commun. 2019 May 21;10(1):2261.

G150 (cGAS inhibitor G150)

生物&药学活性

物理化学性质&存储条件

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G150 (cGAS inhibitor G150)

生物&药学活性

物理化学性质&存储条件

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