G-744 |CAS:1346669-54-2 Probechem Biochemicals

Chemical Structure : G-744

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G-744 (G 744;G744)

货号: PC-60364Not For Human Use, Lab Use Only.

G-744 is a highly potent, selective inhibitor of BTK with biochemical Ki of 1.28 nM.

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生物&药学活性

G-744 is a highly potent, selective inhibitor of BTK with biochemical Ki of 1.28 nM; demonstrates >1,000-fold selectivity against a panel 285 kinase (exception with EphA7 and Fgr, 400-800 fold); prevents BCR-mediated CD86 induction (EC50=64 nM), also inhibits BCR-stimulated B-cell proliferation in human B-cells (EC50=22 nM), abrogates production of TNFα in human monocytes (EC50=33 nM); demonstrates efficacy in the developing CIA model in rats.

物理化学性质&存储条件

分子量	527.643
分子式	C29H29N5O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2-(hydroxymethyl)-3-(1-methyl-6-oxo-5-(pyrimidin-4-ylamino)-1,6-dihydropyridin-3-yl)phenyl)-6,6-dimethyl-3,4,6,7-tetrahydro-2H-cyclopenta[4,5]thieno[2,3-c]pyridin-1(5H)-one

参考文献

1. Wang X, et al. ACS Med Chem Lett. 2017 May 3;8(6):608-613.

G-744 (G 744;G744)

生物&药学活性

物理化学性质&存储条件

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G-744 (G 744;G744)

生物&药学活性

物理化学性质&存储条件

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