G-5555 (G5555) | PAK1 inhibitor | Probechem Biochemicals

Chemical Structure : G-5555

CAS No.: 1648863-90-4

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G-5555 (G5555, G 5555)

货号: PC-45665Not For Human Use, Lab Use Only.

G-5555 is a potent and selective p21-activated kinase 1 (PAK1) inhibitor (Ki=3.7 nM).

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5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥2180	In stock
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100 mg		Get quote

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生物&药学活性

G-5555 is a potent and selective p21-activated kinase 1 (PAK1) inhibitor (Ki=3.7 nM).
G-5555 showes excellent kinase selectivity and inhibits only eight out of the 235 kinases with inhibition >70% at 0.1 uM.
G-5555 inhibits S298 phosphorylation of MEK1 in EBC1 cells with IC50 of 69 nM.
G-5555 shows improved potency and selectivity than FRAX1036 (Cat#PC-45644); shows good vivo PK/PD effects.

物理化学性质&存储条件

分子量	492.9574
分子式	C25H25ClN6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 27 mg/mL
Chemical Name/SMILES	Pyrido[2,3-d]pyrimidin-7(8H)-one, 8-[(trans-5-amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methyl-2-pyridinyl)phenyl]-2-(methylamino)-

参考文献

1. Ndubaku CO, et al. ACS Med Chem Lett. 2015 Oct 31;6(12):1241-6.

2. Rudolph J, et al. J Med Chem. 2016 Jun 9;59(11):5520-41.

G-5555 (G5555, G 5555)

生物&药学活性

物理化学性质&存储条件

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G-5555 (G5555, G 5555)

生物&药学活性

物理化学性质&存储条件

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