Gαi2 inhibitor GT-14

Chemical Structure : Gαi2 inhibitor GT-14

加入收藏

货号: PC-26189Not For Human Use, Lab Use Only.

GT-14 is a first-generation small molecule inhibitor of Gαi2 protein, inhibits cancer cell migration and prevents Gαi2 activation.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

GT-14 is a first-generation small molecule inhibitor of Gαi2 protein, inhibits cancer cell migration and prevents Gαi2 activation.
GT-14 (10 uM) significantly inhibited the migratory behavior of the PC3 and DU145 prostate cancer cell lines.
GT-14 (10 uM) blocks the activation of Gαi2 in oxytocin-stimulated prostate cancer PC3 cells, and inhibits the migratory capability of DU145 cells overexpressing the constitutively active form of Gαi2, under basal and EGF-stimulated conditions.
GT-14 blocks the activation of Gαi2 in oxytocin-stimulated prostate cancer PC3 cells.
GT-14 induces the phosphorylation of CREB protein, downstream effector of cAMP production and negatively regulates the migration of the renal and ovarian cancer cell lines.

物理化学性质&存储条件

分子量	264.33
分子式	C17H16N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-4-((1-(1-methyl-1H-indol-2-yl) ethylidene)amino)phenol

参考文献

1. Sarkar M, et al. AAPS J. 2025 Dec 1;28(1):23.

2. Sarkar M, et al. J Pharm Biomed Anal. 2024 Aug 1;245:116183.

3. Caggia S, et al. Cancers (Basel). 2020;12(6).