FzM1 | Fzd4 modulator | Probechem Biochemicals

Chemical Structure : FzM1

CAS No.: 1680196-54-6

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FzM1 (Fzd4 modulator FzM1;FzM 1)

货号: PC-60976Not For Human Use, Lab Use Only.

FzM1 is a negative allosteric modulator of the Frizzled4 (Fzd4) receptor and a Wnt/β-catenin pathway inhibitor with pEC50 value of 5.74 for inhibition of Wnt antagonism.

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5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥2180	In stock
50 mg		Get quote

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生物&药学活性

FzM1 is a negative allosteric modulator of the Frizzled4 (Fzd4) receptor and a Wnt/β-catenin pathway inhibitor with pEC50 value of 5.74 for inhibition of Wnt antagonism.
FzM1 induces conformational changes in Fz4 by interacting with the third intracellular loop, ICL3, inhibiting binding of dishevelled (Dsh) and hampering the formation of the Fz4-Dsh complex that is necessary for β-catenin nuclear transport and ultimately transcription of TCF/LEF-regulated genes.

物理化学性质&存储条件

分子量	360.43
分子式	C21H16N2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(3-Hydroxy-5-(thiophen-2-yl)phenyl)-3-(naphthalen-2-yl)urea

参考文献

1. Generoso SF, et al. Nat Chem Biol. 2015 Apr;11(4):280-6.

2. Riccio G, et al. Biochemistry. 2018 Jan 2. doi: 10.1021/acs.biochem.7b01087.

FzM1 (Fzd4 modulator FzM1;FzM 1)

生物&药学活性

物理化学性质&存储条件

参考文献

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FzM1 (Fzd4 modulator FzM1;FzM 1)

生物&药学活性

物理化学性质&存储条件

参考文献

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