FzM1.8 | Fzd4 agonist | Probechem Biochemicals

Chemical Structure : FzM1.8

CAS No.: 2204290-85-5

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FzM1.8 (FzM 1.8, Fzd4 agonist FzM1.8)

货号: PC-60975Not For Human Use, Lab Use Only.

FzM1.8 is a small molecule, allosteric agonist of the Frizzled receptor Fzd4 with pEC50 of 6.4, potentiates β-catenin pathway in the absence of any WNT ligand.

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25 mg	￥2480	In stock
50 mg	￥3980	In stock
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生物&药学活性

FzM1.8 is a small molecule, allosteric agonist of the Frizzled receptor Fzd4 with pEC50 of 6.4, potentiates β-catenin pathway in the absence of any WNT ligand.
FzM1.8 biases FZD4 signaling toward a FZD4/PI3K axis that culminates into transactivation of β-catenin/TCF activity by the histone acetyltransferase CBP/p300.
FzM1.8 preserves stemness and promotes proliferation of undifferentiated cells.

物理化学性质&存储条件

分子量	322.32
分子式	C18H14N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-Hydroxy-5-(3-(naphthalen-2-yl)ureido)benzoic acid

参考文献

1. Riccio G, et al. Biochemistry. 2018 Jan 2. doi: 10.1021/acs.biochem.7b01087.

FzM1.8 (FzM 1.8, Fzd4 agonist FzM1.8)

生物&药学活性

物理化学性质&存储条件

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FzM1.8 (FzM 1.8, Fzd4 agonist FzM1.8)

生物&药学活性

物理化学性质&存储条件

参考文献

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