Furin-IN-1d | Furin inhibitor | Probechem Biochemicals

Chemical Structure : Furin-IN-1d

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Furin-IN-1d (Furin inhibitor 1d)

货号: PC-70257Not For Human Use, Lab Use Only.

Furin-IN-1d is a small molecule furin inhibitor with Ki of 22 nM.

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生物&药学活性

Furin-IN-1d is a small molecule furin inhibitor with Ki of 22 nM.
Furin-IN-1d shows comparable potency against furin and PC6B (Ki=22 nM), displays >10-fold selectivity over furin-related human PCs, such as PC7, LF and PACE4, and no activity on trypsin.
Furin-IN-1d strongly inhibits PA processing with EC50 values of 4.2 uM, shows no significant cytotoxicity to the cells at concentrations up to 250 uM.

物理化学性质&存储条件

分子量	561.655
分子式	C26H35N13O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,1'-((1R,3S,4S,6R)-4-(2-amino-4-guanidinophenoxy)-6-((4-guanidinonaphthalen-1-yl)oxy)cyclohexane-1,3-diyl)diguanidine

参考文献

1. Jiao GS, et al. Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19707-12.

Furin-IN-1d (Furin inhibitor 1d)

生物&药学活性

物理化学性质&存储条件

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Furin-IN-1d (Furin inhibitor 1d)

生物&药学活性

物理化学性质&存储条件

参考文献

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