Furanodienone

Chemical Structure : Furanodienone

CAS No.: 24268-41-5

加入收藏

货号: PC-24051Not For Human Use, Lab Use Only.

规格	价格	库存
5 mg	￥1180	In stock
10 mg	￥1880	In stock
25 mg	￥2980	In stock
50 mg	￥4880	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Furanodienone is a major bioactive component of sesquiterpenes produced from Rhizoma Curcumae, shows anticancer efficacy against different types of cancer, is a selective pregnane X receptor (PXR) agonist with EC50 of 2.8 uM in GAL4-hPXR-LBD-transfected HG5LN cells.
Furanodienone binds within a sub-pocket of the PXR ligand binding domain (LBD, ITC Kd=4.5 uM), with subsequent alterations in LBD structure.
Furanodienone has potent PXR-dependant anti-inflammatory outcomes that are colon-specific.
Furanodienone significantly mitigate systemic inflammation and colitis in mice with no deleterious effects in other tissues.
Furanodienone induces apoptosis via regulating the PRDX1/MAPKs/p53/caspases signaling axis through NOX4-derived mitochondrial ROS in colorectal cancer cells.

物理化学性质&存储条件

分子量	230.31
分子式	C15H18O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(5E, 9E)-3,6,10-trimethyl-8,11-dihydro-7H-cyclodeca[b]furan-4-one

参考文献

1. Wang X, et al. Nat Commun. 2025 Feb 3;16(1):1280.

2. Jiang Y, et al. Biochem Pharmacol. 2024 Sep;227:116456.

Furanodienone

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Furanodienone

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.