Fumosorinone |CAS:1879030-70-2 Probechem Biochemicals

Chemical Structure : Fumosorinone

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Fumosorinone (Fumos)

货号: PC-61271Not For Human Use, Lab Use Only.

Fumosorinone is a novel potent, selective protein tyrosine phosphatase SHP2 inhibitor with IC50 of 6.31 uM.

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生物&药学活性

Fumosorinone is a novel potent, selective protein tyrosine phosphatase SHP2 inhibitor with IC50 of 6.31 uM.
Fumosorinone shows little to no inhibition toward other human PTPs (2-7 fold over PTP1B, TCPTP and SHP1).
Fumosorinone inhibits Shp2-dependent activation of the Ras/ERK signal pathway downstream of EGFR, and interrupts EGF-induced Gab1-Shp2 association.
Fumosorinone shows little effects on the Shp2-independent ERK1/2 activation induced by PMA or oncogenic Ras.
Fumosorinone down-regulates Src activation, inhibits phosphorylation of Paxillin and prevents tumor cell invasion.
Fumosorinone shows anti-diabetic effect in diabetic KKAy mice.

物理化学性质&存储条件

分子量	477.601
分子式	C29H35NO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,4-dihydroxy-5-(4-hydroxyphenyl)-3-((2E,4E,6E,8E,10R,12R)-2,8,10,12-tetramethyltetradeca-2,4,6,8-tetraenoyl)pyridin-2(1H)-one

参考文献

1. Chen C, et al. Sci Rep. 2015 Dec 2;5:17626.

2. Liu L, et al. Fungal Genet Biol. 2015 Aug;81:191-200.

3. Liu ZQ, et al. Toxicol Appl Pharmacol. 2015 May 15;285(1):61-70.

Fumosorinone (Fumos)

生物&药学活性

物理化学性质&存储条件

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Fumosorinone (Fumos)

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