Fumonisin B1 | Ceramide synthase inhibitor | Probechem Biochemicals

Chemical Structure : Fumonisin B1

CAS No.: 116355-83-0

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Fumonisin B1 (FB1)

货号: PC-61424Not For Human Use, Lab Use Only.

Fumonisin B1 is a mycotoxin produced from F. moniliforme, and an inhibitor of ceramide synthase (sphingosine N-acyltransferase/CerS).

规格	价格	库存
1 mg	￥1880	In stock
5 mg	￥4580	In stock
10 mg		Get quote
25 mg		Get quote

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生物&药学活性

Fumonisin B1 is a mycotoxin produced from F. moniliforme, and an inhibitor of ceramide synthase (sphingosine N-acyltransferase/CerS).
Fumonisin B1 attenuates the response of P388D1 cells to PAF and LPS by inhibiting ceramide formation.
Fumonisin B1 blocks the apoptotic response of HaCaT cells to the antiproliferative drug hexadecylphosphocholine, through inhibition of ceramide production.
Fumonisin B1 alteres cell morphology and decreases in cell proliferation in Swiss 3T3 cells.

物理化学性质&存储条件

分子量	721.8
分子式	C34H59NO15
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R,2’R)-1,2,3-propanetricarboxylic acid, 1,1’-[(1S,2R)-1-[(2S,4R,9R,11S,12S)-12-amino-4,9,11-trihydroxy-2-methyltridecyl]-2-[(1R)-1-methylpentyl]-1,2-ethanediyl] ester

参考文献

1. Merrill AH Jr, et al. J Biol Chem. 1993 Dec 25;268(36):27299-306.

2. Balsinde J, et al. J Biol Chem. 1997 Aug 15;272(33):20373-7.

3. Meivar-Levy I, et al. J Biol Chem. 1999 Feb 19;274(8):4607-12.

Fumonisin B1 (FB1)

生物&药学活性

物理化学性质&存储条件

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Fumonisin B1 (FB1)

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