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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-FtsZ inhibitor C109
FtsZ inhibitor C109

Chemical Structure : FtsZ inhibitor C109

CAS No.:

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FtsZ inhibitor C109 (Compound 10126109)

货号: PC-35818Not For Human Use, Lab Use Only.

FtsZ inhibitor C109 (Compound 10126109) is a broad spectrum antibacterial compound that inhibits the cell division protein FtsZ, inhibits the FtsZ GTPase activity with IC50 of 8.2 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    FtsZ inhibitor C109 (Compound 10126109) is a broad spectrum antibacterial compound that inhibits the cell division protein FtsZ, inhibits the FtsZ GTPase activity with IC50 of 8.2 uM.
    FtsZ inhibitor C109 inhibits both the GTPase and polymerization activities of purified B. cenocepacia FtsZ, prevents divisome formation by altering the localization of the essential cell division protein FtsZ.
    FtsZ inhibitor C109 displayes antibacterial activity against Gram-positive and Gram-negative cystic fibrosis pathogens, including Mycobacterium abscessus.
    C109 effectively cleared B. cenocepacia infection in the Caenorhabditis elegans model and exhibited additive interactions with clinically relevant antibiotics.

    物理化学性质&存储条件

    分子量 285.292
    分子式 C9H7N3O4S2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    methyl 2-((4-nitrobenzo[c][1,2,5]thiadiazol-5-yl)thio)acetate

    参考文献

    1. Hogan AM, et al. Antimicrob Agents Chemother. 2018 Oct 8. pii: AAC.01231-18. doi: 10.1128/AAC.01231-18.

    2. Scoffone VC, et al. Front Microbiol. 2015 Aug 5;6:815. doi: 10.3389/fmicb.2015.00815.

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