Freselestat |CAS:208848-19-5 Probechem Biochemicals

Chemical Structure : Freselestat

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Freselestat (ONO-6818;ONO 6818)

货号: PC-60485Not For Human Use, Lab Use Only.

Freselestat (ONO 6818) is a potent, selective and orally active human neutrophil elastase (HNE) inhibitor with Ki of 12 nM.

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生物&药学活性

Freselestat (ONO 6818) is a potent, selective and orally active human neutrophil elastase (HNE) inhibitor with Ki of 12 nM.
ONO 6818 dispalys >100-fold selectivity over a panel of related proteases including trypsin, pancreatic elastase, collagenase and murine macrophage elastase.
ONO 6818 attenuates HNE-induced increases in lung myeloperoxidase activity, hemoglobin, and neutrophil count, inhibits acute lung injury induced by HNE in rats.

物理化学性质&存储条件

分子量	452.515
分子式	C23H28N6O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(5-amino-6-oxo-2-phenylpyrimidin-1(6H)-yl)-N-(1-(5-(tert-butyl)-1,3,4-oxadiazol-2-yl)-3-methyl-1-oxobutan-2-yl)acetamide

参考文献

1. Ohmoto K, et al. J Med Chem. 2000 Dec 28;43(26):4927-9.

2. Odagaki Y, et al. Bioorg Med Chem. 2001 Mar;9(3):647-51.

3. Kuraki T, et al. Am J Respir Crit Care Med. 2002 Aug 15;166(4):496-500.

Freselestat (ONO-6818;ONO 6818)

生物&药学活性

物理化学性质&存储条件

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Freselestat (ONO-6818;ONO 6818)

生物&药学活性

物理化学性质&存储条件

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