Fraisinib | GARS1 inhibitor | Probechem Biochemicals

Chemical Structure : Fraisinib

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Fraisinib (Meso-(p-acetamidophenyl)-calix(4)pyrrole)

货号: PC-21698Not For Human Use, Lab Use Only.

Fraisinib is a specific and effective inhibitor of glycyl-tRNA synthetase 1 (GARS1), suppresses the synthesis of Ap4A by GARS1 and displays strong anti-tumoral potential.

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生物&药学活性

Fraisinib is a specific and effective inhibitor of glycyl-tRNA synthetase 1 (GARS1), suppresses the synthesis of Ap4A by GARS1 and displays strong anti-tumoral potential.
GARS1 is an enzyme that is essential in protein synthesis by charging tRNA with glycine amino acid.
Fraisinib treatment (10 uM) induces caspase cascade activation, cell cycle arrests at the G0/G1 phase, and apoptosis activation and invasiveness inhibition in A549 cells.
Fraisinib shows no cytotoxic effect on lymphocytes (peripheral blood mononuclear cells, PBMCs) in the 0.1-300 µM concentration range.
Fraisinib (125 mg/kg BW) reduced the size and the weight of tumors in vivo in immunodeficient CD-1 nude mice (Crl:CD1-Foxn1nu).
Fraisinib (0.1–20 µM) inhibited GARS1 activity dose-dependently.
Fraisinib can modulate different biological and molecular pathways related to GARS1 functions in a unique way.

物理化学性质&存储条件

分子量	547.75
分子式	C35H41N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(5,10,10,15,15,20,20-heptamethyl-5H,10H,15H,20H,22H,24H-porphyrin-5-yl)phenyl)acetamide

参考文献

1. Geretto Met al. Sci. Rep. 8, 11075. 2018

2. Ben Toumia I, et al. Front Pharmacol. 2024 Jan 3;14:1258108.

Fraisinib (Meso-(p-acetamidophenyl)-calix(4)pyrrole)

生物&药学活性

物理化学性质&存储条件

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Fraisinib (Meso-(p-acetamidophenyl)-calix(4)pyrrole)

生物&药学活性

物理化学性质&存储条件

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