Fosdagrocorat |CAS:1044535-58-1 Probechem Biochemicals

Chemical Structure : Fosdagrocorat

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Fosdagrocorat (PF-04171327, PF 04171327)

货号: PC-61849Not For Human Use, Lab Use Only.

Fosdagrocorat (PF 04171327) is an orally available, potential dissociated agonist of the glucocorticoid receptor (GR) for the treatment of rheumatoid arthritis, the phosphate ester prodrug of PF-00251802 (dagrocorat)..

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生物&药学活性

Fosdagrocorat (PF-04171327) is an orally available, potential dissociated agonist of the glucocorticoid receptor (GR) for the treatment of rheumatoid arthritis, the phosphate ester prodrug of PF-00251802 (dagrocorat).

物理化学性质&存储条件

分子量	574.537
分子式	C29H30F3N2O5P
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R,4aS,10aR)-4a-benzyl-7-((2-methylpyridin-3-yl)carbamoyl)-2-(trifluoromethyl)-1,2,3,4,4a,9,10,10a-octahydrophenanthren-2-yl dihydrogen phosphate

参考文献

1. Stock T, et al. Int J Rheum Dis. 2017 Aug;20(8):960-970.

2. Miyoshi S, et al. Int J Clin Pharmacol Ther. 2016 Dec;54(12):966-976.

3. Ripp SL, et al. Clin Pharmacol Drug Dev. 2017 Nov 7. doi: 10.1002/cpdd.411.

Fosdagrocorat (PF-04171327, PF 04171327)

生物&药学活性

物理化学性质&存储条件

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Fosdagrocorat (PF-04171327, PF 04171327)

生物&药学活性

物理化学性质&存储条件

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