Forskolin | Adenylate cyclase activator | Probechem Biochemicals

Chemical Structure : Forskolin

CAS No.: 66575-29-9

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Forskolin (Coleonol, Colforsin, HL362)

货号: PC-28416Not For Human Use, Lab Use Only.

Forskolin (Coleonol, Colforsin) is a potent adenylate cyclase activator with IC50 of 41 nM and EC50 of 0.5 uM for type I adenylyl cyclase, is an inducer of intracellular cAMP formation.

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25mg	￥880	In stock
50 mg	￥1280	In stock
100 mg	￥1980	In stock
250 mg		Get quote

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生物&药学活性

Forskolin (Coleonol, Colforsin) is a potent adenylate cyclase activator with IC50 of 41 nM and EC50 of 0.5 uM for type I adenylyl cyclase, is an inducer of intracellular cAMP formation.
Forskolin induces differentiation of various cell types and activates pregnane X receptor (PXR) and FXR.
Forskolin exerts a inotropic effect on the heart, and has platelet antiaggregatory and antihypertensive actions.
Forskolin also induces autophagy.

物理化学性质&存储条件

分子量	410.51
分子式	C22H34O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyldodecahydro-1H-benzo[f]chromen-5-yl acetate

参考文献

1. Robbins JD, et al. J Med Chem. 1996 Jul 5;39(14):2745-52.

2. Matsumiya W, et al. Invest Ophthalmol Vis Sci. 2012 Dec 7;53(13):8029-35.

3. Mayati A, et al. Sci Rep. 2018 Oct 31;8(1):16115.

Forskolin (Coleonol, Colforsin, HL362)

生物&药学活性

物理化学性质&存储条件

参考文献

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Forskolin (Coleonol, Colforsin, HL362)

生物&药学活性

物理化学性质&存储条件

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