Foldlin

Chemical Structure : Foldlin

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货号: PC-20637Not For Human Use, Lab Use Only.

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1 g		Get quote

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生物&药学活性

Foldlin is a small-molecule tool compound that reduces the protein levels of misfolded/aggregated mutant p53, without effect on contact mutants or wild-type p53, Foldlin is small-molecule HSF-1 activator.
Foldlin prevents the formation of stress-induced p53 nuclear inclusion bodies.
Foldlin is able to induce a broad-spectrum heat shock response in the Saos2 osteosarcoma cell line, increases the mRNA and protein expression of HSP70.
Foldlin induces HSF-1-dependent chaperone expression and restore protein folding in multiple conformational disease models.
Foldlin also reduces protein levels of aggregating SOD1 variants.

物理化学性质&存储条件

分子量	332.36
分子式	C20H16N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(O)C1=CC=CC(N2N=C(C)/C(C2=O)=C\C=C\C3=CC=CC=C3)=C1

参考文献

1. Evelyne Naus, et al. Cells. 2023 Mar 21;12(6):960.

2. Calamini B, et al. Nat. Chem. Biol. 2011;8:185–196.

Foldlin

生物&药学活性

物理化学性质&存储条件

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Foldlin

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物理化学性质&存储条件

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