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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-PARP-Fluzoparib
Fluzoparib

Chemical Structure : Fluzoparib

CAS No.: 1358715-18-0

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Fluzoparib (Fuzuloparib, SHR-3162, SHR3162)

货号: PC-36037Not For Human Use, Lab Use Only.

Fluzoparib (Fuzuloparib, SHR-3162) is a novel, potent and orally available inhibitor of PARP with IC50 of 1.46 nM (PARP1).

规格 价格 库存 数量
5 mg ￥1280 In stock
10 mg ￥1980 In stock
25 mg ￥3480 In stock
50 mg ￥5480 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Fluzoparib (Fuzuloparib, SHR-3162) is a novel, potent and orally available inhibitor of PARP with IC50 of 1.46 nM (PARP1).
Fluzoparib (Fuzuloparib, SHR-3162) potently inhibited PARP1 enzyme activity and induced DNA double-strand breaks, G2/M arrest and apoptosis in homologous recombination repair (H)-deficient cells.
Fluzoparib (Fuzuloparib, SHR-3162) preferentially inhibited the proliferation of HR-deficient cells and sensitized both HR-deficient and HR-proficient cells to cytotoxic drugs.
Fluzoparib (Fuzuloparib, SHR-3162) demonstrates superior anti-tumor activity in HR-deficient xenografts models, elicited significantly improved anti-tumor responses without extra toxicity in combination with apatinib or with apatinib plus paclitaxel.

物理化学性质&存储条件

分子量 472.404
分子式 C22H16F4N6O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(4-fluoro-3-(2-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine-7-carbonyl)benzyl)phthalazin-1(2H)-one

参考文献

1. Wang L, et al. Cancer Sci. 2019 Jan 21. doi: 10.1111/cas.13947.

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