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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-HMG-CoA Reductase (HMGCR)-Fluvastatin
Fluvastatin

Chemical Structure : Fluvastatin

CAS No.: 93957-54-1

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Fluvastatin (XU 62-320)

货号: PC-27085Not For Human Use, Lab Use Only.

Fluvastatin (XU 62-320) is a potent, selective and, competitive HMG-CoA reductase (HMGCR) inhibitor with IC50 of 8 nM, also specifically targets the interaction between KRT18 and LDHA, thereby inhibiting meningioma proliferation by suppressing glycolysis and PI3K/AKT signaling.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Fluvastatin (XU 62-320) is a potent, selective and, competitive HMG-CoA reductase (HMGCR) inhibitor with IC50 of 8 nM, also specifically targets the interaction between KRT18 and LDHA, thereby inhibiting meningioma proliferation by suppressing glycolysis and PI3K/AKT signaling.

物理化学性质&存储条件

分子量 411.47
分子式 C24H26FNO4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

rel-(3R,5S,E)-7-(3-(4-Fluorophenyl)-1-isopropyl-1H-indol-2-yl)-3,5-dihydroxyhept-6-enoic acid

参考文献

1. Makabe S, et al. Atherosclerosis. 2010 Dec;213(2):377-84.

2. Li H, et al. Cancer Lett. 2026 Jun 15:218680.

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