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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-HCV-Fluoxazolevir
Fluoxazolevir

Chemical Structure : Fluoxazolevir

CAS No.: 1842323-83-4

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Fluoxazolevir (NCGC00351982, NCGC 00351982)

货号: PC-72891Not For Human Use, Lab Use Only.

Fluoxazolevir (NCGC00351982) is a potent, small molecule entry inhibitor of HCV with EC50 of 18.8 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Fluoxazolevir (NCGC00351982) is a potent, small molecule entry inhibitor of HCV with EC50 of 18.8 nM.
    Fluoxazolevir inhibits fusion of HCV with hepatic cells by binding HCV envelope protein 1 (E1) to prevent fusion.
    Fluoxazolevir was generally effective against all chimeric HCV-RLuc genotypes including 1a, 1b, 2b, 3a, 4a, 5a, 6a and 7a, was most effective against HCV 2a and 2b, followed by 3a and 6a, all within sub-μM EC50 values, with little to no cytotoxicity (CC50>20 uM).
    Fluoxazolevir was highly synergistic with other anti-HCV drugs (interferon-α, ribavirin, daclatasvir, sofosbuvir and simeprevir (NS3/4A protease inhibitor)).
    Fluoxazolevir suppresses HCV infection in humanized chimeric mice, and is active against multidrug-resistant HCV.
    Fluoxazolevir also broadly blocked human coronavirus entry into various cell types, inhibit SARS-CoV S- and SARS-CoV-2 S-mediated infection MA104 cells with EC50 of 6.49 and 3.86 uM, respectively.

    物理化学性质&存储条件

    分子量 470.633
    分子式 C27H39FN4O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(3-((3S,5R)-3,5-dimethylpiperidin-1-yl)propyl)-1-((2-(4-fluoro-3-methylphenyl)oxazol-4-yl)methyl)piperidine-4-carboxamide

    参考文献

    1. Christopher D Ma, et al. Nat Microbiol. 2020 Dec;5(12):1532-1541.

    2. Shanshan He, et al. J Med Chem. 2017 Jul 27;60(14):6364-6383.

    3. Park SB, et al. mBio. 2022 Jan 11;13(1):e0323821.

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