Fluorofolin

Chemical Structure : Fluorofolin

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货号: PC-22130Not For Human Use, Lab Use Only.

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25 mg		Get quote
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250 mg		Get quote

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生物&药学活性

Fluorofolin is a potent bacterial dihydrofolate reductase (DHFR) inhibitor with IC50 of 2.5 nM for purified E. coli DHFR (FolA), exhibits potent activity against P. aeruginosa PA14 with MIC of 3.1 ug/mL.
Fluorofolin has broad-spectrum antibiotic activity, is capable of inhibiting growth of two other strains of P. aeruginosa, PA01 and ATTC 27853, as well as all 5 of the ESKAPE28 pathogens at <50 ug/mL.
Fluorofolin exhibits modest specificity with IC50 of 14.0 nM for purified human DHFR.
Fluorofolin inhibits folate metabolism in P. aeruginosa cells.
Fluorofolin inhibits murine thigh infection of P. aeruginosa, selectively targets P. aeruginosa with exogenous thymine.

物理化学性质&存储条件

分子量	308.32
分子式	C16H13FN6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-((2-fluoropyridin-4-yl)methyl)-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine

参考文献

1. Chain C, et al. Nat Microbiol. 2024 Apr 9. doi: 10.1038/s41564-024-01665-2.

Fluorofolin

生物&药学活性

物理化学性质&存储条件

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Fluorofolin

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