Chemical Structure : Flucopride
货号: PC-23392Not For Human Use, Lab Use Only.
Flucopride is a potent, dual serotonin subtype 4 receptor (5-HT4R) agonist/acetylcholinesterase (AChE) inhibitor with Ki of 9.6 nM (5-HT4R) and IC50 of 24 nM (hAChE).
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Flucopride is a potent, dual serotonin subtype 4 receptor (5-HT4R) agonist/acetylcholinesterase (AChE) inhibitor with Ki of 9.6 nM (5-HT4R) and IC50 of 24 nM (hAChE).
Flucopride is 250 times more potent for AChE (IC50 = 24 nM) than for (eq)BuChE (IC50 = 6.2 μM).
Flucopride promotes the non-amyloidogenic processing of APP in COS-7 transiently expressing (h)5-HT4 receptors with EC50 of 23.0 nM.
Flucopride (10 mg/kg) decreases spontaneous locomotor activity in vivo, reverses the scopolamine-induced spontaneous alternation deficit.
分子量 | 376.52 | |
分子式 | C22H33FN2O2 | |
外观性状 | Solid | |
储存条件 |
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Solubility |
10 mM in DMSO |
1. Rochais C, et al. Eur J Med Chem. 2024 Oct 18;280:116975.
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