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Fleroxacin

Chemical Structure : Fleroxacin

CAS No.: 79660-72-3

Fleroxacin (AM833, Ro 23-6240, NN 9838, NNC0174-0833)

货号: PC-49008Not For Human Use, Lab Use Only.

Fleroxacin (AM833, Ro23-6240) is a broad-spectrum fluoroquinolone antibiotic, with activity against a variety of Gram-positive and Gram-negative bacteria with MIC90 values of 0.05 to 3.13 ug/mL.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Fleroxacin (AM833, Ro23-6240) is a broad-spectrum fluoroquinolone antibiotic, with activity against a variety of Gram-positive and Gram-negative bacteria with MIC90 values of 0.05 to 3.13 ug/mL.
Fleroxacin (AM833, Ro23-6240) showed potent activity against members of the family Enterobacteriaceae, Neisseria spp., and Haemophilus influenzae and good activity against staphylococci, Pseudomonas aeruginosa, and Branhamella catarrhalis.
Fleroxacin (AM833, Ro23-6240) was as effective as ofloxacin and ciprofloxacin against systemic infections with Escherichia coli and Pseudomonas aeruginosa.
AM-833 exhibited good prophylactic activity against E. coli infections.
AM-833 also proved effective against localized infections such acute pneumonia and ascending urinary tract infections in mice.

物理化学性质&存储条件

分子量 369.344
分子式 C17H18F3N3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

6,8-difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid

参考文献

1. Chin NX, et al. Antimicrob Agents Chemother. 1986 Apr;29(4):675-80.

2. Hirai K, et al. Antimicrob Agents Chemother. 1986 Jun;29(6):1059-66.

3. Manek N, et al. Antimicrob Agents Chemother. 1986 Aug;30(2):330-2.

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