Chemical Structure : Flecainide acetate
CAS No.: 54143-56-5
货号: PC-45252Not For Human Use, Lab Use Only.
A class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias, works by blocking the Nav1.5 sodium channel in the heart, slowing the upstroke of the cardiac action potential.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
25 mg | ¥1180 | In stock | |
50 mg | ¥1780 | In stock | |
100 mg | ¥2680 | In stock | |
250 mg | Get quote |
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Flecainide acetate (R-818) is a class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias, works by blocking the Nav1.5 sodium channel in the heart, slowing the upstroke of the cardiac action potential.
Flecainide acetate also inhibits ryanodine receptor 2 (RyR2), reduces calcium sparks and thus arrhythmogenic calcium waves in the heart.
分子量 | 474.3947 | |
分子式 | C19H24F6N2O5 | |
外观性状 | Solid | |
储存条件 |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
Benzamide, N-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)-, acetate (1:1) |
1. Hilliard FA, et al. J Mol Cell Cardiol. 2010 Feb;48(2):293-301.
2. Salvage SC, et al. Acta Physiol (Oxf). 2015 Jul;214(3):361-75.
3. Salvage SC, et al. Br J Pharmacol. 2017 Apr 3. doi: 10.1111/bph.13807.
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