Flavokawain B |CAS:1775-97-9 Probechem Biochemicals

Chemical Structure : Flavokawain B

CAS No.: 1775-97-9

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Flavokawain B

货号: PC-35324Not For Human Use, Lab Use Only.

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5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3480	In stock
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100 mg		Get quote

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生物&药学活性

Flavokawain B is a natural chalcone that can induce apoptosis in androgen receptor-negative, hormone-refractory prostate cancer cell lines (IC50=3-50 uM), via up-regulation of death-receptor 5 (DR5) and Bim expression.
Flavokawain B induces apoptosis in human myeloid leukemic cells by modifying NF-κB, possesses potential anti-inflammation and anti-cancer activities.
Flavokawain B also exhibits significant inhibition of the neurogenic nociceptive induced by intraplantar injections of glutamate and capsaicin in mice.

物理化学性质&存储条件

分子量	284.311
分子式	C17H16O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Propen-1-one, 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenyl-, (E)-

参考文献

1. Tang Y, et al. Int J Cancer. 2010 Oct 15;127(8):1758-68.

2. Lee JJ, et al. Anticancer Res. 2018 May;38(5):2771-2778.

3. Mohamad AS, et al. Eur J Pharmacol. 2010 Nov 25;647(1-3):103-9.

4. Abu N, et al. Nat Prod Commun. 2015 Jul;10(7):1199-202.

Flavokawain B

生物&药学活性

物理化学性质&存储条件

参考文献

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Flavokawain B

生物&药学活性

物理化学性质&存储条件

参考文献

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